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Membranes 2016, 6(1), 8; doi:10.3390/membranes6010008

Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features

Neuroscience and Signalling Laboratory, Department of Medical Sciences, Institute of Biomedicine—iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
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Academic Editor: Shiro Suetsugu
Received: 30 October 2015 / Revised: 5 January 2016 / Accepted: 6 January 2016 / Published: 15 January 2016
(This article belongs to the Section Biological Membranes (Transport Processes))
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Abstract

Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1’s precise function has not been fully elucidated but analysis of its interacting proteins will permit unraveling putative associations to specific cellular pathways and cellular processes. By assessing public databases it was possible to identify the LAP1 interactome, and this was curated. In total, 41 interactions were identified. Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1. Furthermore, by making use of the Ingenuity Pathways Analysis tool and submitting the LAP1 interactors, the top two canonical pathways were “Telomerase signalling” and “Telomere Extension by Telomerase” and the top functions “Cell Morphology”, “Cellular Assembly and Organization” and “DNA Replication, Recombination, and Repair”. Once again, putative LAP1 functions are reinforced but novel functions are emerging. View Full-Text
Keywords: Lamina associated polypeptide; nuclear envelope; Inner nuclear membrane; interactors; network; database; Cytoscape; GeneMANIA; GO terms enrichment analysis; Ingenuity pathway analysis Lamina associated polypeptide; nuclear envelope; Inner nuclear membrane; interactors; network; database; Cytoscape; GeneMANIA; GO terms enrichment analysis; Ingenuity pathway analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Serrano, J.B.; da Cruz e Silva, O.A.B.; Rebelo, S. Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features. Membranes 2016, 6, 8.

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