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Membranes 2016, 6(1), 6; doi:10.3390/membranes6010006

Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis

1
Department of Biomedical Engineering, University of Rochester, 252 Elmwood Ave, Rochester, NY 14627, USA
2
Department of Mechanical Engineering, University of Rochester, 252 Elmwood Ave, Rochester, NY 14627, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Spas Kolev
Received: 14 December 2015 / Revised: 28 December 2015 / Accepted: 28 December 2015 / Published: 31 December 2015
(This article belongs to the Special Issue Membranes in Medicine and Biology)
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Abstract

Hemodialysis involves large, periodic treatment doses using large-area membranes. If the permeability of dialysis membranes could be increased, it would reduce the necessary dialyzer size and could enable a wearable device that administers a continuous, low dose treatment of chronic kidney disease. This paper explores the application of ultrathin silicon membranes to this purpose, by way of analytical and finite element models of diffusive and convective transport of plasma solutes during hemodialysis, which we show to be predictive of experimental results. A proof-of-concept miniature nanomembrane dialyzer design is then proposed and analytically predicted to clear uremic toxins at near-ideal levels, as measured by several markers of dialysis adequacy. This work suggests the feasibility of miniature nanomembrane-based dialyzers that achieve therapeutic levels of uremic toxin clearance for patients with kidney failure. View Full-Text
Keywords: hemodialysis; membranes; dialysis membranes; models; diffusion; continuous dialysis; wearable artificial kidney; nanomembranes hemodialysis; membranes; dialysis membranes; models; diffusion; continuous dialysis; wearable artificial kidney; nanomembranes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Burgin, T.; Johnson, D.; Chung, H.; Clark, A.; McGrath, J. Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis. Membranes 2016, 6, 6.

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