Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis
AbstractHemodialysis involves large, periodic treatment doses using large-area membranes. If the permeability of dialysis membranes could be increased, it would reduce the necessary dialyzer size and could enable a wearable device that administers a continuous, low dose treatment of chronic kidney disease. This paper explores the application of ultrathin silicon membranes to this purpose, by way of analytical and finite element models of diffusive and convective transport of plasma solutes during hemodialysis, which we show to be predictive of experimental results. A proof-of-concept miniature nanomembrane dialyzer design is then proposed and analytically predicted to clear uremic toxins at near-ideal levels, as measured by several markers of dialysis adequacy. This work suggests the feasibility of miniature nanomembrane-based dialyzers that achieve therapeutic levels of uremic toxin clearance for patients with kidney failure. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Burgin, T.; Johnson, D.; Chung, H.; Clark, A.; McGrath, J. Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis. Membranes 2016, 6, 6.
Burgin T, Johnson D, Chung H, Clark A, McGrath J. Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis. Membranes. 2016; 6(1):6.Chicago/Turabian Style
Burgin, Tucker; Johnson, Dean; Chung, Henry; Clark, Alfred; McGrath, James. 2016. "Analytical and Finite Element Modeling of Nanomembranes for Miniaturized, Continuous Hemodialysis." Membranes 6, no. 1: 6.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.