Membrane Binding and Modulation of the PDZ Domain of PICK1
AbstractScaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function. View Full-Text
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Erlendsson, S.; Madsen, K.L. Membrane Binding and Modulation of the PDZ Domain of PICK1. Membranes 2015, 5, 597-615.
Erlendsson S, Madsen KL. Membrane Binding and Modulation of the PDZ Domain of PICK1. Membranes. 2015; 5(4):597-615.Chicago/Turabian Style
Erlendsson, Simon; Madsen, Kenneth L. 2015. "Membrane Binding and Modulation of the PDZ Domain of PICK1." Membranes 5, no. 4: 597-615.