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Membranes 2015, 5(3), 307-351; doi:10.3390/membranes5030307

Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges

1
Technical University of Denmark, Department of Environmental Engineering, Miljøvej, Building 113, 2800 Kgs. Lyngby, Denmark
2
Aquaporin A/S, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark
3
University of Copenhagen, Department of Plant and Environmental Sciences, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark
4
University of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
5
University of Copenhagen, Niels Bohr Institute, Hans Christian Ørsted building D, Universitetsparken, 5, 2100 Copenhagen, Denmark
6
Technical University of Denmark, Department of Micro- and Nanotechnology, Produktionstorvet, Building 423, 2800 Kgs. Lyngby
7
University of Maribor, Laboratory for Water Biophysics and Membrane Processes, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editors: Chuyang Y. Tang and Zhining Wang
Received: 8 July 2015 / Accepted: 22 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Biomimetic Membranes)
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Abstract

In recent years, aquaporin biomimetic membranes (ABMs) for water separation have gained considerable interest. Although the first ABMs are commercially available, there are still many challenges associated with further ABM development. Here, we discuss the interplay of the main components of ABMs: aquaporin proteins (AQPs), block copolymers for AQP reconstitution, and polymer-based supporting structures. First, we briefly cover challenges and review recent developments in understanding the interplay between AQP and block copolymers. Second, we review some experimental characterization methods for investigating AQP incorporation including freeze-fracture transmission electron microscopy, fluorescence correlation spectroscopy, stopped-flow light scattering, and small-angle X-ray scattering. Third, we focus on recent efforts in embedding reconstituted AQPs in membrane designs that are based on conventional thin film interfacial polymerization techniques. Finally, we describe some new developments in interfacial polymerization using polyhedral oligomeric silsesquioxane cages for increasing the physical and chemical durability of thin film composite membranes. View Full-Text
Keywords: biomimetic membranes; aquaporins; block copolymers; proteopolymersomes; polyhedral oligomeric silsesquioxanes; polyamide layer; microfluidics; membrane proteins; protein-polymer-interactions biomimetic membranes; aquaporins; block copolymers; proteopolymersomes; polyhedral oligomeric silsesquioxanes; polyamide layer; microfluidics; membrane proteins; protein-polymer-interactions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Habel, J.; Hansen, M.; Kynde, S.; Larsen, N.; Midtgaard, S.R.; Jensen, G.V.; Bomholt, J.; Ogbonna, A.; Almdal, K.; Schulz, A.; Hélix-Nielsen, C. Aquaporin-Based Biomimetic Polymeric Membranes: Approaches and Challenges. Membranes 2015, 5, 307-351.

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