Membranes 2011, 1(4), 394-411; doi:10.3390/membranes1040394
Review

Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane

1email, 1email, 1,2email and 1,* email
Received: 31 October 2011; in revised form: 28 November 2011 / Accepted: 5 December 2011 / Published: 13 December 2011
(This article belongs to the Special Issue Biological Membrane Morphogenesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Studies on the budding yeast Saccharomyces cerevisiae have revealed that fungal plasma membranes are organized into different subdomains. One new domain termed MCC/eisosomes consists of stable punctate patches that are distinct from lipid rafts. The MCC/eisosome domains correspond to furrows in the plasma membrane that are about 300 nm long and 50 nm deep. The MCC portion includes integral membrane proteins, such as the tetraspanners Sur7 and Nce102. The adjacent eisosome includes proteins that are peripherally associated with the membrane, including the BAR domains proteins Pil1 and Lsp1 that are thought to promote membrane curvature. Genetic analysis of the MCC/eisosome components indicates these domains broadly affect overall plasma membrane organization. The mechanisms regulating the formation of MCC/eisosomes in model organisms will be reviewed as well as the role of these plasma membrane domains in fungal pathogenesis and response to antifungal drugs.
Keywords: MCC; eisosome; Pil1; Lsp1; Sur7; Nce102; plasma membrane; cell wall; yeast; hyphae
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MDPI and ACS Style

Douglas, L.M.; Wang, H.X.; Li, L.; Konopka, J.B. Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane. Membranes 2011, 1, 394-411.

AMA Style

Douglas LM, Wang HX, Li L, Konopka JB. Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane. Membranes. 2011; 1(4):394-411.

Chicago/Turabian Style

Douglas, Lois M.; Wang, Hong X.; Li, Lifang; Konopka, James B. 2011. "Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane." Membranes 1, no. 4: 394-411.

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