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Membranes 2011, 1(1), 3-12; doi:10.3390/membranes1010003

The Fabrication of Biomimetic Chitosan Scaffolds by Using SBF Treatment with Different Crosslinking Agents

Department of Chemical Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Road, Da’an District, 10617 Taipei, Taiwan
Author to whom correspondence should be addressed.
Received: 7 October 2010 / Accepted: 8 December 2010 / Published: 15 December 2010
(This article belongs to the Special Issue Selected Papers from the AMS6/IMSTEC10 Conference)
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In this study, a chitosan substrate was modified by simulated body fluid (SBF) treatment, in which the effect of the chosen crosslinking agent was investigated. Two crosslinking agents, glutaraldehyde (GA) and sodium tripolyphosphate (TPP), were used before the SBF process. By using TPP as the crosslinking agent, the Ca/P ratio and the degree of crystallinity were very close to the natural bone matrix. On the contrary, the substrate properties were very different from natural bone when the crosslinking agent GA was used. The results indicate that the produced substrates were biomimetic when the TPP was applied. On the SBF-modified chitosan substrates with TPP crosslinking, the cultured osteoblastic cells expressed better proliferation, mitochondria activity and differentiation ability. The chitosan crosslinked using TPP was a good template in the SBF process, which resulted in a highly biomimetic layer. This biomimetic substrate possesses excellent biocompatibility and osteoconduction ability, promising high potential in the promotion of bone tissue engineering. View Full-Text
Keywords: chitosan; biomimetic; SBF; osteoconduction; tissue engineering; crosslinking chitosan; biomimetic; SBF; osteoconduction; tissue engineering; crosslinking

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liao, C.-T.; Ho, M.-H. The Fabrication of Biomimetic Chitosan Scaffolds by Using SBF Treatment with Different Crosslinking Agents. Membranes 2011, 1, 3-12.

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