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Vaccines 2017, 5(3), 30; doi:10.3390/vaccines5030030

Host Transcriptional Response to Ebola Virus Infection

Department of Microbiology, Bioinformatics Program, National Emerging Infectious Disease Laboratories, Boston University, Boston, MA 02118, USA
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Author to whom correspondence should be addressed.
Academic Editors: Angela L. Rasmussen and Juliet Morrison
Received: 4 August 2017 / Revised: 12 September 2017 / Accepted: 12 September 2017 / Published: 20 September 2017
(This article belongs to the Special Issue Host Responses to Viral Infection)
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Abstract

Ebola virus disease (EVD) is a serious illness that causes severe disease in humans and non-human primates (NHPs) and has mortality rates up to 90%. EVD is caused by the Ebolavirus and currently there are no licensed therapeutics or vaccines to treat EVD. Due to its high mortality rates and potential as a bioterrorist weapon, a better understanding of the disease is of high priority. Multiparametric analysis techniques allow for a more complete understanding of a disease and the host response. Analysis of RNA species present in a sample can lead to a greater understanding of activation or suppression of different states of the immune response. Transcriptomic analyses such as microarrays and RNA-Sequencing (RNA-Seq) have been important tools to better understand the global gene expression response to EVD. In this review, we outline the current knowledge gained by transcriptomic analysis of EVD. View Full-Text
Keywords: Ebola virus disease; host response; transcriptomic; RNA-Seq; microarray; immune response Ebola virus disease; host response; transcriptomic; RNA-Seq; microarray; immune response
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Speranza, E.; Connor, J.H. Host Transcriptional Response to Ebola Virus Infection. Vaccines 2017, 5, 30.

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