Next Article in Journal / Special Issue
Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification
Previous Article in Journal / Special Issue
Peptide Vaccine: Progress and Challenges
Article Menu

Export Article

Open AccessReview
Vaccines 2014, 2(3), 537-548; doi:10.3390/vaccines2030537

Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses

The University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane QLD 4102, Australia
Received: 9 April 2014 / Revised: 13 May 2014 / Accepted: 5 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Peptide Vaccine)
View Full-Text   |   Download PDF [498 KB, uploaded 2 July 2014]   |  

Abstract

While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells. View Full-Text
Keywords: vaccination; T cell avidity; altered peptide ligands; peptide dose; peptide structure; peptide vaccines; functional avidity vaccination; T cell avidity; altered peptide ligands; peptide dose; peptide structure; peptide vaccines; functional avidity
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leggatt, G.R. Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses. Vaccines 2014, 2, 537-548.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top