The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk
AbstractThe nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H2O2 in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases. View Full-Text
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Chen, C.; Li, L.; Zhou, H.J.; Min, W. The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk. Antioxidants 2017, 6, 42.
Chen C, Li L, Zhou HJ, Min W. The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk. Antioxidants. 2017; 6(2):42.Chicago/Turabian Style
Chen, Chaofei; Li, Li; Zhou, Huanjiao J.; Min, Wang. 2017. "The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk." Antioxidants 6, no. 2: 42.