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Roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase in Angiogenesis: Isoform-Specific Effects
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Antioxidants 2017, 6(2), 42; doi:10.3390/antiox6020042

The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk

1
Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
2
Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Masuko Ushio-Fukai
Received: 18 April 2017 / Revised: 31 May 2017 / Accepted: 2 June 2017 / Published: 8 June 2017
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
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Abstract

The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family is the major source of reactive oxygen species (ROS) in the vascular system. In this family, NOX4, a constitutive active form of NOXs, plays an important role in angiogenesis. Thioredoxin 2 (TRX2) is a key mitochondrial redox protein that maintains normal protein function and also provides electrons to peroxiredoxin 3 (PRX3) to scavenge H2O2 in mitochondria. Angiogenesis, a process of new blood vessel formation, is involved in a variety of physiological processes and pathological conditions. It seems to be paradoxical for ROS-producing NOX4 and ROS-scavenging TRX2 to have a similar role in promoting angiogenesis. In this review, we will focus on data supporting the role of NOX4 and TRX2 in angiogenesis and their cross-talks and discuss how ROS can positively or negatively regulate angiogenesis, depending on their species, levels and locations. NOX4 and TRX2-mediated ROS signaling could be promising targets for the treatment of angiogenesis-related diseases. View Full-Text
Keywords: angiogenesis; NOX4; TRX2; ROS angiogenesis; NOX4; TRX2; ROS
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Chen, C.; Li, L.; Zhou, H.J.; Min, W. The Role of NOX4 and TRX2 in Angiogenesis and Their Potential Cross-Talk. Antioxidants 2017, 6, 42.

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