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Antioxidants 2017, 6(2), 41; doi:10.3390/antiox6020041

Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies

1
Clinical Physiology Institute, National Research Council, 56124 Pisa, Italy
2
Fondazione Regione Toscana G. Monasterio, 56124 Pisa, Italy
3
Cardiovascular Department, Ospedale della Bassa val di Cecina, 57123 Cecina, Italy
4
Department of Cardiology, Ruby General Hospital, Kolkata 700107, India
5
Centre National de Cardiologie, Nouakchott 000, Mauritania
6
Cardiovascular Department, San Camillo Hospital, 00152 Roma, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Dejian Huang
Received: 24 April 2017 / Revised: 31 May 2017 / Accepted: 6 June 2017 / Published: 8 June 2017
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
View Full-Text   |   Download PDF [678 KB, uploaded 8 June 2017]   |  

Abstract

The increased life expectancy, urbanization, and unhealthy lifestyle characterized by a shift towards a sedentary lifestyle and decreased energy expenditure are considered the main drivers of epidemiological transition. In particular, developing countries are facing a double burden caused by coexisting under- and over-nutrition, which causes a change in the disease profile from infectious diseases to a chronic degenerative pattern. This review discusses the under- and over-nutrition context in Mauritania and India, two countries that are experiencing a nutritional transition, and where we began a collaboration with local medical staff to integrate interventional and diagnostic guidelines. If many studies about diet and its relationship to non-communicable diseases are available for India, very few nutrition and cardiovascular risk studies have been conducted in Mauritania. Presently, with the exponential increase of nutrition-related diseases, targeted approaches are needed to provide balanced diets in parallel with the development of national preventive health systems and screening programs adapted to local needs. In this context, the measurement of oxidative stress biomarkers could be promising as an additive tool to assess cardiovascular (CV) risk in general population, and ameliorating prevention in patients at CV risk or with overt CV disease. Moreover, the possibility of improving the outcome by the direct employment of antioxidant remains plausible. Moreover, studies on the content of antioxidant in different foods may be helpful to develop a balanced diet, and achieve the maximal nutritional and functional properties of cultivars with benefits for human health. View Full-Text
Keywords: nutrition; epidemiological transition; non-communicable diseases; cardiovascular disease; inflammatory biomarkers; antioxidants; oxidative stress biomarkers nutrition; epidemiological transition; non-communicable diseases; cardiovascular disease; inflammatory biomarkers; antioxidants; oxidative stress biomarkers
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MDPI and ACS Style

Mastorci, F.; Vassalle, C.; Chatzianagnostou, K.; Marabotti, C.; Siddiqui, K.; Eba, A.O.; Mhamed, S.A.S.; Bandopadhyay, A.; Nazzaro, M.S.; Passera, M.; Pingitore, A. Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. Antioxidants 2017, 6, 41.

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