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Antioxidants 2017, 6(2), 26; doi:10.3390/antiox6020026

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

1
Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy
2
Centre for Molecular and Translational Oncology (COMT), University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy
3
National Institute of Biostructure and Biosystems (INBB), Viale Medaglie d’Oro 305, Rome 00136, Italy
4
Fondazione Umberto Veronesi, Piazza Velasca 5, Milan 20122, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: H.P. Vasantha Rupasinghe
Received: 13 March 2017 / Revised: 1 April 2017 / Accepted: 3 April 2017 / Published: 5 April 2017
(This article belongs to the Special Issue Plant Polyphenols in Cancer Chemoprevention)
View Full-Text   |   Download PDF [681 KB, uploaded 5 April 2017]   |  

Abstract

Green tea catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human prostate cancer (PCa) chemoprevention. In the last decades, many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs’ anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets, including cell surface receptors, lipid rafts, and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, and interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentrations that cannot be achieved in vivo. Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs’ bioavailability through still poorly understood mechanisms. Recent efforts to develop delivery systems that increase GTCs’ overall bioavailability, by means of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention. View Full-Text
Keywords: green tea catechins; prostate cancer; chemoprevention; nanochemoprevention; antioxidant; mechanism of action green tea catechins; prostate cancer; chemoprevention; nanochemoprevention; antioxidant; mechanism of action
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MDPI and ACS Style

Naponelli, V.; Ramazzina, I.; Lenzi, C.; Bettuzzi, S.; Rizzi, F. Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges. Antioxidants 2017, 6, 26.

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