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Antioxidants 2017, 6(1), 9; doi:10.3390/antiox6010009

Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv

College of Pharmacy, Chicago State University, Chicago, IL 60628, USA
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Author to whom correspondence should be addressed.
Academic Editors: Isabel C. F. R. Ferreira and Stanley Omaye
Received: 15 December 2016 / Revised: 9 January 2017 / Accepted: 24 January 2017 / Published: 28 January 2017
(This article belongs to the Special Issue Feature Papers 2016)
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Abstract

Borututu (Cochlospermum angolensis) is an African tree whose bark has recently emerged as a herbal dietary supplement with claims for antioxidant activity. In order to substantiate the claimed activity of borututu supplements, we performed an activity-guided fractionation of the total extract utilizing a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Subsequent flash and centrifugal chromatography resulted in the isolation of gallic acid (1) and protocatechuic acid (2) as the main antioxidant constituents. Two apocarotenoids and one flavonoid were also isolated from the chloroform fraction and were identified as cochloxanthin (3), dihydrocochloxanthin (4), and 7,4′-dimethyltaxifolin (5), respectively. A High-performance liquid chromatography (HPLC) method was also developed for fingerprinting borututu samples, with Compounds 14 suggested as chemical markers for quality control purposes. View Full-Text
Keywords: flash chromatography; centrifugal thin-layer chromatography; phenolic acids; apocarotenoids; antioxidants; DPPH scavenging; HPLC fingerprinting flash chromatography; centrifugal thin-layer chromatography; phenolic acids; apocarotenoids; antioxidants; DPPH scavenging; HPLC fingerprinting
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MDPI and ACS Style

Abourashed, E.A.; Fu, H.W. Hydroxybenzoic Acids Are Significant Contributors to the Antioxidant Effect of Borututu Bark, Cochlospermum angolensis Welw. ex Oliv. Antioxidants 2017, 6, 9.

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