Next Article in Journal
Oxidation Stability of Pig Liver Pâté with Increasing Levels of Natural Antioxidants (Grape and Tea)
Next Article in Special Issue
Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome
Previous Article in Journal / Special Issue
Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
Article Menu

Export Article

Open AccessArticle
Antioxidants 2015, 4(1), 82-101; doi:10.3390/antiox4010082

Antioxidant Approaches to Management of Ionizing Irradiation Injury

1,* , 2,†
,
3,†
,
4,5,6,†
and
1,†
1
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Rm. 533, Pittsburgh, PA 15232, USA
2
Department of Environmental/Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
3
Department of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
4
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
5
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
6
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Nikolai Gorbunov
Received: 5 December 2014 / Accepted: 12 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Redox Stress and Redox Homeostatic Response to Trauma and Injury)
View Full-Text   |   Download PDF [687 KB, uploaded 23 January 2015]   |  

Abstract

Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiation tissue and organ injury. The development of antioxidant therapies to ameliorate ionizing irradiation injury began with initial studies on gene therapy using Manganese Superoxide Dismutase (MnSOD) transgene approaches and evolved into applications of small molecule radiation protectors and mitigators. The understanding of the multiple steps in ionizing radiation-induced cellular, tissue, and organ injury, as well as total body effects is required to optimize the use of antioxidant therapies, and to sequence such approaches with targeted therapies for the multiple steps in the irradiation damage response. View Full-Text
Keywords: ionizing irradiation; antioxidants; oxidative stress; mitochondrial mechanisms of apoptosis ionizing irradiation; antioxidants; oxidative stress; mitochondrial mechanisms of apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Greenberger, J.; Kagan, V.; Bayir, H.; Wipf, P.; Epperly, M. Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants 2015, 4, 82-101.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top