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Antioxidants 2014, 3(4), 830-842; doi:10.3390/antiox3040830

Rosmarinic Acid, a New Polyphenol from Baccaurea ramiflora Lour. Leaf: A Probable Compound for Its Anti-Inflammatory Activity

1
Department of Biotechnology, Maharani Lakshmi Ammanni College for Women, Bangalore-560012, India
2
Department of Botany, Kalimpong College, Kalimpong-734301, India
3
Padmashree Institute of Management and Science, Bangalore-560060, India
4
Bamboo Technology, Department of Biotechnology, Bodoland University, Kokrajhar-783370, India
*
Author to whom correspondence should be addressed.
Received: 11 August 2014 / Revised: 20 November 2014 / Accepted: 20 November 2014 / Published: 3 December 2014
(This article belongs to the Special Issue Analytical Determination of Polyphenols)
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Abstract

Despite several pharmacological applications of Baccaurea ramiflora Lour., studies on the influence of its polyphenol content on pharmacological activity such as anti-inflammatory properties have been scarce. Here we evaluated in vitro antioxidant activity, poyphenolics by HPLC and the anti-inflammatory potential of the methanolic leaf extract of Baccaurea ramiflora (BME) and its protective effects in carrageenan-induced paw edema model of inflammation in rats. The BME extract contained 79.06 ± 0.03 mg gallic acid equivalent (GAE)/g total polyphenols, 28.80 ± 0.01 mg quercetin equivalent (QE)/g flavonoid and 29.42 ± 0.01 μg cathechin equivalent/g proanthocyanidin respectively and rosmarinic acid (8 mg/kg) as a main component was identified by HPLC. Results demonstrate that administration of BME at the dose of 200 mg/kg can reduce paw edema by over 63%, and it exhibits a dose-response effect. Depending on concentration, the extract exerted scavenging activity on DPPH radical (IC50 36.4 μg/mL), significantly inhibited IL-1β (4.4 pg/mg protein) and TNF-α (0.21 ng/μg protein). Therefore, we conclude BME causes a substantial reduction of inflammation in in vivo models. We propose that rosmarinic acid and similar phenolic compounds may be useful in the therapy of inflammation-related injuries. View Full-Text
Keywords: Baccaurea ramiflora; rosmarinic acid; anti-inflammatory activity; cytokines Baccaurea ramiflora; rosmarinic acid; anti-inflammatory activity; cytokines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Usha, T.; Middha, S.K.; Bhattacharya, M.; Lokesh, P.; Goyal, A.K. Rosmarinic Acid, a New Polyphenol from Baccaurea ramiflora Lour. Leaf: A Probable Compound for Its Anti-Inflammatory Activity. Antioxidants 2014, 3, 830-842.

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