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From the third issue of 2017, Microarrays has changed its name to High-Throughput.

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Microarrays 2016, 5(3), 20; doi:10.3390/microarrays5030020

The Potentials and Pitfalls of Microarrays in Neglected Tropical Diseases: A Focus on Human Filarial Infections

1
Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Private Mail Bag, Kwame Nkrumah University Science & Technology, KNUST, Kumasi 233, Ghana
2
Department of Biochemistry and Biotechnology, Kwame Nkrumah University Science & Technology, KNUST, Kumasi 233, Ghana
*
Author to whom correspondence should be addressed.
Academic Editor: Phillip Stafford
Received: 19 February 2016 / Revised: 1 June 2016 / Accepted: 28 June 2016 / Published: 2 August 2016
(This article belongs to the Special Issue Microarrays in Immunology Research)
View Full-Text   |   Download PDF [1176 KB, uploaded 2 August 2016]   |  

Abstract

Data obtained from expression microarrays enables deeper understanding of the molecular signatures of infectious diseases. It provides rapid and accurate information on how infections affect the clustering of gene expression profiles, pathways and networks that are transcriptionally active during various infection states compared to conventional diagnostic methods, which primarily focus on single genes or proteins. Thus, microarray technologies offer advantages in understanding host-parasite interactions associated with filarial infections. More importantly, the use of these technologies can aid diagnostics and helps translate current genomic research into effective treatment and interventions for filarial infections. Studying immune responses via microarray following infection can yield insight into genetic pathways and networks that can have a profound influence on the development of anti-parasitic vaccines. View Full-Text
Keywords: microarray; transcriptomics; filarial; whole blood; signaling pathways microarray; transcriptomics; filarial; whole blood; signaling pathways
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kwarteng, A.; Ahuno, S.T. The Potentials and Pitfalls of Microarrays in Neglected Tropical Diseases: A Focus on Human Filarial Infections. Microarrays 2016, 5, 20.

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