Next Article in Journal
Stromal Activation by Tumor Cells: An in Vitro Study in Breast Cancer
Next Article in Special Issue
Modeling Hybridization Kinetics of Gene Probes in a DNA Biochip Using FEMLAB
Previous Article in Journal
Time-Resolved Study of Nanoparticle Induced Apoptosis Using Microfabricated Single Cell Arrays
Previous Article in Special Issue
Evaluating the Effect of Cell Culture on Gene Expression in Primary Tissue Samples Using Microfluidic-Based Single Cell Transcriptional Analysis
Article Menu

Export Article

From the third issue of 2017, Microarrays has changed its name to High-Throughput.

Open AccessReview
Microarrays 2016, 5(2), 9; doi:10.3390/microarrays5020009

Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi

Department of Microbiology and Immunology, New York Medical College, School of Medicine, Valhalla, NY 10595, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Zvi Loewy
Received: 7 March 2016 / Revised: 28 March 2016 / Accepted: 11 April 2016 / Published: 16 April 2016
(This article belongs to the Special Issue Microfluidics Technology)
View Full-Text   |   Download PDF [619 KB, uploaded 16 April 2016]   |  

Abstract

Borrelia burgdorferi, the spirochetal agent of Lyme disease, is maintained in nature in a cycle involving a tick vector and a mammalian host. Adaptation to the diverse conditions of temperature, pH, oxygen tension and nutrient availability in these two environments requires the precise orchestration of gene expression. Over 25 microarray analyses relating to B. burgdorferi genomics and transcriptomics have been published. The majority of these studies has explored the global transcriptome under a variety of conditions and has contributed substantially to the current understanding of B. burgdorferi transcriptional regulation. In this review, we present a summary of these studies with particular focus on those that helped define the roles of transcriptional regulators in modulating gene expression in the tick and mammalian milieus. By performing comparative analysis of results derived from the published microarray expression profiling studies, we identified composite gene lists comprising differentially expressed genes in these two environments. Further, we explored the overlap between the regulatory circuits that function during the tick and mammalian phases of the enzootic cycle. Taken together, the data indicate that there is interplay among the distinct signaling pathways that function in feeding ticks and during adaptation to growth in the mammal. View Full-Text
Keywords: microarray; Borrelia burgdorferi; transcriptome; Lyme disease; transcriptional regulators microarray; Borrelia burgdorferi; transcriptome; Lyme disease; transcriptional regulators
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Iyer, R.; Schwartz, I. Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi. Microarrays 2016, 5, 9.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Microarrays EISSN 2076-3905 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top