Neuromodulatory Treatments for Alcohol Use Disorder: A Review
AbstractAlcohol use disorder (AUD) is a prevalent condition characterized by chronic alcohol-seeking behaviors and has become a significant economic burden with global ramifications on public health. While numerous treatment options are available for AUD, many are unable to sustain long-term sobriety. The nucleus accumbens (NAcc) upholds an integral role in mediating reward behavior and has been implicated as a potential target for deep brain stimulation (DBS) in the context of AUD. DBS is empirically thought to disrupt pathological neuronal synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot human clinical studies utilizing DBS for the treatment of AUD have shown promise for reducing alcohol-related cravings and prolonging abstinence. In this review, we outline the various interventions available for AUD, and the translational potential DBS has to modulate functionality of the NAcc as a treatment for AUD. View Full-Text
Share & Cite This Article
Salib, A.-M.N.; Ho, A.L.; Sussman, E.S.; Pendharkar, A.V.; Halpern, C.H. Neuromodulatory Treatments for Alcohol Use Disorder: A Review. Brain Sci. 2018, 8, 95.
Salib A-MN, Ho AL, Sussman ES, Pendharkar AV, Halpern CH. Neuromodulatory Treatments for Alcohol Use Disorder: A Review. Brain Sciences. 2018; 8(6):95.Chicago/Turabian Style
Salib, Anne-Mary N.; Ho, Allen L.; Sussman, Eric S.; Pendharkar, Arjun V.; Halpern, Casey H. 2018. "Neuromodulatory Treatments for Alcohol Use Disorder: A Review." Brain Sci. 8, no. 6: 95.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.