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Brain Sci. 2018, 8(6), 110; https://doi.org/10.3390/brainsci8060110

Chaperonology: The Third Eye on Brain Gliomas

1
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, Italy
2
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, Italy
3
Euro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, Italy
4
Institute of Biophysics, National Research Council, 90143 Palermo, Italy
5
Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USA
These authors contributed equally to the work.
*
Author to whom correspondence should be addressed.
Received: 10 May 2018 / Revised: 5 June 2018 / Accepted: 13 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue Optimizing Management of High Grade Glioma)
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Abstract

The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents. View Full-Text
Keywords: high-grade gliomas; molecular chaperones; heat shock proteins; neuroimaging; neuromonitoring; chaperonology; chaperonotherapy high-grade gliomas; molecular chaperones; heat shock proteins; neuroimaging; neuromonitoring; chaperonology; chaperonotherapy
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Graziano, F.; Bavisotto, C.C.; Gammazza, A.M.; Rappa, F.; de Macario, E.C.; Macario, A.J.L.; Cappello, F.; Campanella, C.; Maugeri, R.; Iacopino, D.G. Chaperonology: The Third Eye on Brain Gliomas. Brain Sci. 2018, 8, 110.

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