Next Article in Journal
Chaperonology: The Third Eye on Brain Gliomas
Next Article in Special Issue
Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination
Previous Article in Journal
Depression among Black Youth; Interaction of Class and Place
Previous Article in Special Issue
The Effect of Axon Resealing on Retrograde Neuronal Death after Spinal Cord Injury in Lamprey
Article Menu

Export Article

Open AccessReview
Brain Sci. 2018, 8(6), 109; https://doi.org/10.3390/brainsci8060109

History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair

1,2,3,4
and
2,3,4,*
1
Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN 47450, USA
2
Spinal Cord and Brain Injury Research, Indiana University School of Medicine, Indianapolis, IN 47450, USA
3
Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 47450, USA
4
Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN 47450, USA
*
Author to whom correspondence should be addressed.
Received: 17 May 2018 / Revised: 10 June 2018 / Accepted: 11 June 2018 / Published: 13 June 2018
(This article belongs to the Special Issue Novel Mechanisms and Strategies for Neural Repair)
View Full-Text   |   Download PDF [499 KB, uploaded 13 June 2018]   |  

Abstract

Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, in combination with other factors and cell transplantations, for repairing the injured spinal cord. As studies of recent decades strongly suggest that combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed. View Full-Text
Keywords: spinal cord injury; glial cell line-derived neurotrophic factor (GDNF); GFRα-1; cRET; Schwann cells; astrogliosis; neuroprotection; axonal regeneration; combinational therapies; neurotrauma spinal cord injury; glial cell line-derived neurotrophic factor (GDNF); GFRα-1; cRET; Schwann cells; astrogliosis; neuroprotection; axonal regeneration; combinational therapies; neurotrauma
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Walker, M.J.; Xu, X.-M. History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair. Brain Sci. 2018, 8, 109.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top