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Brain Sci. 2018, 8(4), 53; https://doi.org/10.3390/brainsci8040053

Down Syndrome, Obesity, Alzheimer’s Disease, and Cancer: A Brief Review and Hypothesis

1
Cancer Treatment Centers of America, Southeastern Regional Medical Center, Newnan, GA 30265, USA
2
Morehouse School of Medicine, Atlanta, GA 30310, USA
Received: 24 February 2018 / Revised: 15 March 2018 / Accepted: 22 March 2018 / Published: 24 March 2018
View Full-Text   |   Download PDF [309 KB, uploaded 3 May 2018]

Abstract

Down syndrome (trisomy 21), a complex mix of physical, mental, and biochemical issues, includes an increased risk of Alzheimer’s disease and childhood leukemia, a decreased risk of other tumors, and a high frequency of overweight/obesity. Certain features related to the third copy of chromosome 21 (which carries the APP gene and several anti-angiogenesis genes) create an environment favorable for Alzheimer’s disease and unfavorable for cancer. This environment may be enhanced by two bioactive compounds from fat cells, leptin, and adiponectin. This paper outlines these fat-related disease mechanisms and suggests new avenues of research to reduce disease risk in Down syndrome. View Full-Text
Keywords: down syndrome; cancer; Alzheimer’s disease; obesity; leptin; adiponectin down syndrome; cancer; Alzheimer’s disease; obesity; leptin; adiponectin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nixon, D.W. Down Syndrome, Obesity, Alzheimer’s Disease, and Cancer: A Brief Review and Hypothesis. Brain Sci. 2018, 8, 53.

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