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Brain Sci. 2017, 7(5), 48; doi:10.3390/brainsci7050048

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

1
Department of Oncology, University of Cambridge, Hutchison-MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
2
Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
3
Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK
4
Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti, 9, Milan 20133, Italy
5
Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kazuhito Toyooka
Received: 22 March 2017 / Revised: 21 April 2017 / Accepted: 24 April 2017 / Published: 27 April 2017
(This article belongs to the Special Issue Neuronal Migration and Cortical Development)
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Abstract

Neuronal migration is a fundamental biological process that underlies proper brain development and neuronal circuit formation. In the developing cerebral cortex, distinct neuronal populations, producing excitatory, inhibitory and modulatory neurotransmitters, are generated in different germinative areas and migrate along various routes to reach their final positions within the cortex. Different technical approaches and experimental models have been adopted to study the mechanisms regulating neuronal migration in the cortex. In this review, we will discuss the most common in vitro, ex vivo and in vivo techniques to visualize and study cortical neuronal migration. View Full-Text
Keywords: migrating neuron; cortex; migration assays; electroporation migrating neuron; cortex; migration assays; electroporation
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MDPI and ACS Style

Azzarelli, R.; Oleari, R.; Lettieri, A.; Andre', V.; Cariboni, A. In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex. Brain Sci. 2017, 7, 48.

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