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Brain Sci. 2016, 6(4), 58; doi:10.3390/brainsci6040058

Improvement of Advanced Parkinson’s Disease Manifestations with Deep Brain Stimulation of the Subthalamic Nucleus: A Single Institution Experience

1
Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612, USA
2
Department of Neurosurgery, Alexandria University, Alexandria, Egypt
3
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
4
Department of Neurology, Alexandria University, Alexandria, Egypt
5
Department of Neurosurgery, Tanta University, Tanta, Egypt
*
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Received: 9 September 2016 / Revised: 3 December 2016 / Accepted: 5 December 2016 / Published: 13 December 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
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Abstract

We present our experience at the University of Illinois at Chicago (UIC) in deep brain stimulation (DBS) of the subthalamic nucleus (STN), describing our surgical technique, and reporting our clinical results, and morbidities. Twenty patients with advanced Parkinson’s disease (PD) who underwent bilateral STN-DBS were studied. Patients were assessed preoperatively and followed up for one year using the Unified Parkinson’s Disease Rating Scale (UPDRS) in “on” and “off” medication and “on” and “off” stimulation conditions. At one-year follow-up, we calculated significant improvement in all the motor aspects of PD (UPDRS III) and in activities of daily living (UPDRS II) in the “off” medication state. The “off” medication UPDRS improved by 49.3%, tremors improved by 81.6%, rigidity improved by 50.0%, and bradykinesia improved by 39.3%. The “off” medication UPDRS II scores improved by 73.8%. The Levodopa equivalent daily dose was reduced by 54.1%. The UPDRS IVa score (dyskinesia) was reduced by 65.1%. The UPDRS IVb score (motor fluctuation) was reduced by 48.6%. Deep brain stimulation of the STN improves the cardinal motor manifestations of the idiopathic PD. It also improves activities of daily living, and reduces medication-induced complications. View Full-Text
Keywords: subthalamic nucleus; deep brain stimulation; Parkinson’s disease; neuromodulation; clinical outcome subthalamic nucleus; deep brain stimulation; Parkinson’s disease; neuromodulation; clinical outcome
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MDPI and ACS Style

Rabie, A.; Verhagen Metman, L.; Fakhry, M.; Eassa, A.Y.E.; Fouad, W.; Shakal, A.; Slavin, K.V. Improvement of Advanced Parkinson’s Disease Manifestations with Deep Brain Stimulation of the Subthalamic Nucleus: A Single Institution Experience. Brain Sci. 2016, 6, 58.

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