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Brain Sci. 2016, 6(3), 39; doi:10.3390/brainsci6030039

Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study

1
Department of Biomedical Engineering, Linköping University, Linköping 58185, Sweden
2
Department of Neurosurgery, Linköping University Hospital, Region Östergötland, Linköping 58185, Sweden
3
Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Received: 30 June 2016 / Revised: 29 August 2016 / Accepted: 30 August 2016 / Published: 7 September 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
View Full-Text   |   Download PDF [7053 KB, uploaded 7 September 2016]   |  

Abstract

New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode and capability to steer the electric field (EF). The aim of the study was to compare the EF distributions of four DBS leads at equivalent amplitudes (3 V and 3.4 mA). Finite element method (FEM) simulations (n = 38) around cylindrical contacts (leads 3389, 6148) or equivalent contact configurations (leads 6180, SureStim1) were performed using homogeneous and patient-specific (heterogeneous) brain tissue models. Steering effects of 6180 and SureStim1 were compared with symmetric stimulation fields. To make relative comparisons between simulations, an EF isolevel of 0.2 V/mm was chosen based on neuron model simulations (n = 832) applied before EF visualization and comparisons. The simulations show that the EF distribution is largely influenced by the heterogeneity of the tissue, and the operating mode. Equivalent contact configurations result in similar EF distributions. In steering configurations, larger EF volumes were achieved in current mode using equivalent amplitudes. The methodology was demonstrated in a patient-specific simulation around the zona incerta and a “virtual” ventral intermediate nucleus target. In conclusion, lead design differences are enhanced when using patient-specific tissue models and current stimulation mode. View Full-Text
Keywords: deep brain stimulation (DBS); steering; patient-specific; electric field; finite element method; neuron model; brain model; zona incerta (ZI); electrode design deep brain stimulation (DBS); steering; patient-specific; electric field; finite element method; neuron model; brain model; zona incerta (ZI); electrode design
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alonso, F.; Latorre, M.A.; Göransson, N.; Zsigmond, P.; Wårdell, K. Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study. Brain Sci. 2016, 6, 39.

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