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Brain Sci. 2016, 6(3), 38; doi:10.3390/brainsci6030038

Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety

1
Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
2
Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
3
Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, Düsseldorf 40225, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Received: 15 July 2016 / Revised: 18 August 2016 / Accepted: 22 August 2016 / Published: 30 August 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
View Full-Text   |   Download PDF [1559 KB, uploaded 30 August 2016]   |  

Abstract

Huntington’s disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD. View Full-Text
Keywords: chorea; Huntington; deep brain stimulation; DBS; safety pathophysiology; recordings; globus pallidus chorea; Huntington; deep brain stimulation; DBS; safety pathophysiology; recordings; globus pallidus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wojtecki, L.; Groiss, S.J.; Hartmann, C.J.; Elben, S.; Omlor, S.; Schnitzler, A.; Vesper, J. Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety. Brain Sci. 2016, 6, 38.

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