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Brain Sci. 2015, 5(2), 241-257; doi:10.3390/brainsci5020241

Hippocampal Cortactin Levels are Reduced Following Spatial Working Memory Formation, an Effect Blocked by Chronic Calpain Inhibition

Department of Psychology and Program in Neuroscience, Concordia College, Moorhead, MN 56562, USA
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Academic Editor: Germán Barrionuevo
Received: 22 December 2014 / Revised: 12 May 2015 / Accepted: 12 June 2015 / Published: 19 June 2015
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Abstract

The mechanism by which the hippocampus facilitates declarative memory formation appears to involve, among other things, restructuring of the actin cytoskeleton within neuronal dendrites. One protein involved in this process is cortactin, which is an important link between extracellular signaling and cytoskeletal reorganization. In this paper, we demonstrate that total hippocampal cortactin, as well as Y421-phosphorylated cortactin are transiently reduced following spatial working memory formation in the radial arm maze (RAM). Because cortactin is a substrate of the cysteine protease calpain, we also assessed the effect of chronic calpain inhibition on RAM performance and cortactin expression. Calpain inhibition impaired spatial working memory and blocked the reduction in hippocampal cortactin levels following RAM training. These findings add to a growing body of research implicating cortactin and calpain in hippocampus-dependent memory formation. View Full-Text
Keywords: radial arm maze; hippocampus; spatial working memory; cortactin; calpain radial arm maze; hippocampus; spatial working memory; cortactin; calpain
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MDPI and ACS Style

Olson, M.L.; Ingebretson, A.E.; Harmelink, K.M. Hippocampal Cortactin Levels are Reduced Following Spatial Working Memory Formation, an Effect Blocked by Chronic Calpain Inhibition. Brain Sci. 2015, 5, 241-257.

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