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Brain Sci. 2013, 3(3), 1182-1197; doi:10.3390/brainsci3031182

Repair of the Peripheral Nerve—Remyelination that Works

Institute of Molecular Medicine—Neurobiology Research, University of Southern Denmark, J.B. Winsløws vej 21.1, Odense DK-5000, Denmark
Department of Clinical Sciences, Hand Surgery, Lund University, Skåne University Hospital, Malmö SE-20502, Sweden
Author to whom correspondence should be addressed.
Received: 24 June 2013 / Revised: 7 July 2013 / Accepted: 19 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Myelin Repair)
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In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge about the initial events after injury, followed by Wallerian degeneration, and subsequent regeneration. The importance of surgical repair, carried out as soon as possible to increase the chances of a good outcome, is emphasized throughout the review. The review concludes by describing the target re-innervation, which today is one of the most serious problems for nerve regeneration. It is clear, compiling this data, that even though regeneration of the peripheral nervous system is possible, more research in this area is needed in order to perfect the outcome. View Full-Text
Keywords: peripheral nerve injury; Schwann cell; proliferation; bands of Büngner; nerve regeneration; myelination; target innervation; nerve repair peripheral nerve injury; Schwann cell; proliferation; bands of Büngner; nerve regeneration; myelination; target innervation; nerve repair

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Svennigsen, Å.F.; Dahlin, L.B. Repair of the Peripheral Nerve—Remyelination that Works. Brain Sci. 2013, 3, 1182-1197.

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