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Appl. Sci. 2018, 8(7), 1098; https://doi.org/10.3390/app8071098

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

1
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), C/Melchor Fernández-Almagro 3, 28029 Madrid, Spain
2
Centro de Investigación Biomédica en Red (CIBERES), 28029 Madrid, Spain
3
CIC biomaGUNE, Paseo de Miramón 182, 20014 Donostia-San Sebastián, Spain
4
Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain
5
Departamento Química Física II, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 17 May 2018 / Revised: 15 June 2018 / Accepted: 29 June 2018 / Published: 6 July 2018
(This article belongs to the Special Issue Advanced Isotopic Techniques for In Vivo Imaging)
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Abstract

The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging. View Full-Text
Keywords: Gallium-68; radio-nanomaterials; molecular imaging; biomedical imaging; nanoparticles; radiochemistry; nanomedicine Gallium-68; radio-nanomaterials; molecular imaging; biomedical imaging; nanoparticles; radiochemistry; nanomedicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Fernández-Barahona, I.; Muñoz-Hernando, M.; Pellico, J.; Ruiz-Cabello, J.; Herranz, F. Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles. Appl. Sci. 2018, 8, 1098.

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