Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus
AbstractZinc sulfate monohydrate (ZnSO4)-loaded nanocomposites (NCs) were fabricated by using a hot-melt extruder (HME) system. Soluplus (SP) was adopted as an amphiphilic polymer matrix for HME processing. The micro-size of ZnSO4 dispersion was reduced to nano-size by HME processing with the use of SP. ZnSO4 could be homogeneously dispersed in SP through HME processing. ZnSO4/SP NCs with a 75 nm mean diameter, a 0.1 polydispersity index, and a −1 mV zeta potential value were prepared. The physicochemical properties of ZnSO4/SP NCs and the existence of SP in ZnSO4/SP NCs were further investigated by solid-state studies. Nano-size range of ZnSO4/SP NC dispersion was maintained in the simulated gastrointestinal environments (pH 1.2 and 6.8 media). No severe toxicity in intestinal epithelium after oral administration of ZnSO4/SP NCs (at 100 mg/kg dose of ZnSO4, single dosing) was observed in rats. These results imply that developed ZnSO4/SP NC can be used as a promising nano-sized zinc supplement formulation. In addition, developed HME technology can be widely applied to fabricate nanoformulations of inorganic materials. View Full-Text
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Lee, S.Y.; Nam, S.; Choi, Y.; Kim, M.; Koo, J.S.; Chae, B.-J.; Kang, W.-S.; Cho, H.-J. Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Appl. Sci. 2017, 7, 902.
Lee SY, Nam S, Choi Y, Kim M, Koo JS, Chae B-J, Kang W-S, Cho H-J. Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Applied Sciences. 2017; 7(9):902.Chicago/Turabian Style
Lee, Song Y.; Nam, Suyeong; Choi, Yohan; Kim, Minju; Koo, Ja S.; Chae, Byung-Jo; Kang, Wie-Soo; Cho, Hyun-Jong. 2017. "Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus." Appl. Sci. 7, no. 9: 902.
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