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Appl. Sci. 2017, 7(9), 902; doi:10.3390/app7090902

Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus

1
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea
2
Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Korea
3
School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Korea
These authors equally contributed to this work.
*
Author to whom correspondence should be addressed.
Received: 20 July 2017 / Revised: 30 August 2017 / Accepted: 1 September 2017 / Published: 4 September 2017
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
View Full-Text   |   Download PDF [5176 KB, uploaded 5 September 2017]   |  

Abstract

Zinc sulfate monohydrate (ZnSO4)-loaded nanocomposites (NCs) were fabricated by using a hot-melt extruder (HME) system. Soluplus (SP) was adopted as an amphiphilic polymer matrix for HME processing. The micro-size of ZnSO4 dispersion was reduced to nano-size by HME processing with the use of SP. ZnSO4 could be homogeneously dispersed in SP through HME processing. ZnSO4/SP NCs with a 75 nm mean diameter, a 0.1 polydispersity index, and a −1 mV zeta potential value were prepared. The physicochemical properties of ZnSO4/SP NCs and the existence of SP in ZnSO4/SP NCs were further investigated by solid-state studies. Nano-size range of ZnSO4/SP NC dispersion was maintained in the simulated gastrointestinal environments (pH 1.2 and 6.8 media). No severe toxicity in intestinal epithelium after oral administration of ZnSO4/SP NCs (at 100 mg/kg dose of ZnSO4, single dosing) was observed in rats. These results imply that developed ZnSO4/SP NC can be used as a promising nano-sized zinc supplement formulation. In addition, developed HME technology can be widely applied to fabricate nanoformulations of inorganic materials. View Full-Text
Keywords: hot-melt extrusion; nanocomposite; Soluplus; zinc sulfate monohydrate hot-melt extrusion; nanocomposite; Soluplus; zinc sulfate monohydrate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, S.Y.; Nam, S.; Choi, Y.; Kim, M.; Koo, J.S.; Chae, B.-J.; Kang, W.-S.; Cho, H.-J. Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Appl. Sci. 2017, 7, 902.

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