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Appl. Sci. 2017, 7(7), 706; doi:10.3390/app7070706

A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model

1
Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n 03202-Elche, Alicante, Spain
2
Instituto de Cerámica y Vidrio, ICV-CSIC, C/Kelsen 5, 28049 Madrid, Spain
3
Biotecnos Research Center, Rua Dr. Bonazo nº 57 Santa Maria (RS), 97015-001, Brasil
4
Cátedra Internacional de Investigación en Odontología, Universidad Católica San Antonio de Murcia, Avda. Jerónimos, 135, 30107 Guadalupe, Murcia, Spain
*
Author to whom correspondence should be addressed.
Received: 5 June 2017 / Revised: 29 June 2017 / Accepted: 6 July 2017 / Published: 8 July 2017
(This article belongs to the Section Materials)
View Full-Text   |   Download PDF [1693 KB, uploaded 8 July 2017]   |  

Abstract

We herein hypothesize that bioceramics with an appropriate architecture made of Si-αtricalcium phosphate (Si-αTCP) meet the biocompatibility and biological safety requirements for bone grafting applications. Polyurethane sponges were used as templates, soaked with ceramic slurry at different ratios and sintered at 1400 °C for 3 h at heating and cooling rates of 5 °C/min. Four critical size defects of 6 mm Ø were created in 15 NZ tibias. Three working times were established as 15, 30 and 60 days. A highly porous Si-αTCP scaffold with micro and macropores and pore interconnectivity was produced by the polymer replication method. Considerably more bone formation took place in the pores and the periphery of the implant for the Si-αTCP scaffolds than for the control group. The ceramic scaffold (68.32% ± 1.21) generated higher bone-to-implant contact (BIC) percentage values (higher quality, closer contact) than the control group, according to the histomorphometric analysis, and defect closure was significant compared with the control group. The highest percentages of BIC and bone formation were found after 60 days of implantation. These results suggest that the Si-αTCP scaffold is advantageous for initial bone regeneration. View Full-Text
Keywords: polymer replication method; porous bioceramics; tricalcium phosphate; in vivo response; tissue reaction; biocompatibility polymer replication method; porous bioceramics; tricalcium phosphate; in vivo response; tissue reaction; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

De Aza, P.N.; Rodríguez, M.A.; Gehrke, S.A.; Maté-Sánchez de Val, J.E.; Calvo-Guirado, J.L. A Si-αTCP Scaffold for Biomedical Applications: An Experimental Study Using the Rabbit Tibia Model. Appl. Sci. 2017, 7, 706.

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