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Appl. Sci. 2017, 7(12), 1320; doi:10.3390/app7121320

Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China
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Received: 14 October 2017 / Revised: 29 October 2017 / Accepted: 30 October 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Biomedical Photoacoustic and Thermoacoustic Imaging)
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Abstract

Since its introduction to the field in mid-1990s, photoacoustic imaging has become a fast-developing biomedical imaging modality with many promising potentials. By converting absorbed diffused light energy into not-so-diffused ultrasonic waves, the reconstruction of the ultrasonic waves from the targeted area in photoacoustic imaging leads to a high-contrast sensing of optical absorption with ultrasonic resolution in deep tissue, overcoming the optical diffusion limit from the signal detection perspective. The generation of photoacoustic signals, however, is still throttled by the attenuation of photon flux due to the strong diffusion effect of light in tissue. Recently, optical wavefront shaping has demonstrated that multiply scattered light could be manipulated so as to refocus inside a complex medium, opening up new hope to tackle the fundamental limitation. In this paper, the principle and recent development of photoacoustic imaging and optical wavefront shaping are briefly introduced. Then we describe how photoacoustic signals can be used as a guide star for in-tissue optical focusing, and how such focusing can be exploited for further enhancing photoacoustic imaging in terms of sensitivity and penetration depth. Finally, the existing challenges and further directions towards in vivo applications are discussed. View Full-Text
Keywords: photoacoustic imaging; optical scattering; optical diffusion limit; penetration depth; wavefront shaping; iterative optimization; transmission matrix; Grueneisen effect; noninvasive internal guide star photoacoustic imaging; optical scattering; optical diffusion limit; penetration depth; wavefront shaping; iterative optimization; transmission matrix; Grueneisen effect; noninvasive internal guide star
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Yu, Z.; Li, H.; Lai, P. Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging. Appl. Sci. 2017, 7, 1320.

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