Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging
AbstractSince its introduction to the field in mid-1990s, photoacoustic imaging has become a fast-developing biomedical imaging modality with many promising potentials. By converting absorbed diffused light energy into not-so-diffused ultrasonic waves, the reconstruction of the ultrasonic waves from the targeted area in photoacoustic imaging leads to a high-contrast sensing of optical absorption with ultrasonic resolution in deep tissue, overcoming the optical diffusion limit from the signal detection perspective. The generation of photoacoustic signals, however, is still throttled by the attenuation of photon flux due to the strong diffusion effect of light in tissue. Recently, optical wavefront shaping has demonstrated that multiply scattered light could be manipulated so as to refocus inside a complex medium, opening up new hope to tackle the fundamental limitation. In this paper, the principle and recent development of photoacoustic imaging and optical wavefront shaping are briefly introduced. Then we describe how photoacoustic signals can be used as a guide star for in-tissue optical focusing, and how such focusing can be exploited for further enhancing photoacoustic imaging in terms of sensitivity and penetration depth. Finally, the existing challenges and further directions towards in vivo applications are discussed. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yu, Z.; Li, H.; Lai, P. Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging. Appl. Sci. 2017, 7, 1320.
Yu Z, Li H, Lai P. Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging. Applied Sciences. 2017; 7(12):1320.Chicago/Turabian Style
Yu, Zhipeng; Li, Huanhao; Lai, Puxiang. 2017. "Wavefront Shaping and Its Application to Enhance Photoacoustic Imaging." Appl. Sci. 7, no. 12: 1320.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.