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Appl. Sci. 2017, 7(11), 1175; https://doi.org/10.3390/app7111175

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

1
Anhui Provice Key Laboratory of Optoelectronic and Magnetism Functional Materials, Anqing Normal University, Anqing 246011, China
2
Hybrid Materials Interfaces Group, Faculty of Production Engineering and Center for Environmental Research and Sustainable Technology (UFT), University of Bremen, D-28359 Bremen, Germany
3
MAPEX Center for Materials and Processes, University of Bremen, Am Fallturm 1, D-28359 Bremen, Germany
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 30 October 2017 / Accepted: 13 November 2017 / Published: 15 November 2017
(This article belongs to the Special Issue Graphene and Graphene Oxide in Biomedical Application)
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Abstract

Graphene-based nanomaterials have exhibited wide applications in nanotechnology, materials science, analytical science, and biomedical engineering due to their unique physical and chemical properties. In particular, graphene has been an excellent nanocarrier for drug delivery application because of its two-dimensional structure, large surface area, high stability, good biocompatibility, and easy surface modification. In this review, we present the recent advances in the synthesis and drug delivery application of graphene-based nanomaterials. The modification of graphene and the conjugation of graphene with other materials, such as small molecules, nanoparticles, polymers, and biomacromolecules as functional nanohybrids are introduced. In addition, the controlled drug delivery with the fabricated graphene-based nanomaterials are demonstrated in detail. It is expected that this review will guide the chemical modification of graphene for designing novel functional nanohybrids. It will also promote the potential applications of graphene-based nanomaterials in other biomedical fields, like biosensing and tissue engineering. View Full-Text
Keywords: graphene; modification; nanoparticles; polymer; nanohybrids; drug delivery; biomedical application graphene; modification; nanoparticles; polymer; nanohybrids; drug delivery; biomedical application
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, Z.; Colombi Ciacchi, L.; Wei, G. Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery. Appl. Sci. 2017, 7, 1175.

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