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Appl. Sci. 2016, 6(9), 184; doi:10.3390/app6090184

Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method

Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advance Technology (ITMA), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Department of Physics, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Department of Crop Science, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia
Department of Applied Science and Humanities, Sasi Intitute of Technology and Engineering, Tadepalligudem, West Godavari District-534101, Andhra Pradesh, India
Author to whom correspondence should be addressed.
Academic Editor: Philippe Lambin
Received: 28 December 2015 / Revised: 29 February 2016 / Accepted: 2 March 2016 / Published: 30 August 2016
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
View Full-Text   |   Download PDF [2885 KB, uploaded 30 August 2016]   |  


Spinel copper ferrite (CuFe2O4) and zinc ferrite (ZnFe2O4) nanoparticles were synthesized using a sol-gel self-combustion technique. The structural, functional, morphological and magnetic properties of the samples were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and vibrating sample magnetometry (VSM). XRD patterns conform to the copper ferrite and zinc ferrite formation, and the average particle sizes were calculated by using a transmission electron microscope, the measured particle sizes being 56 nm for CuFe2O4 and 68 nm for ZnFe2O4. Both spinel ferrite nanoparticles exhibit ferromagnetic behavior with saturation magnetization of 31 emug−1 for copper ferrite (50.63 Am2/Kg) and 28.8 Am2/Kg for zinc ferrite. Both synthesized ferrite nanoparticles were equally effective in scavenging 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) free radicals. ZnFe2O4 and CuFe2O4 nanoparticles showed 30.57% ± 1.0% and 28.69% ± 1.14% scavenging activity at 125 µg/mL concentrations. In vitro cytotoxicity study revealed higher concentrations (>125 µg/mL) of ZnFe2O4 and CuFe2O4 with increased toxicity against MCF-7 cells, but were found to be non-toxic at lower concentrations suggesting their biocompatibility. View Full-Text
Keywords: copper ferrite; zinc ferrite; nanoparticles; cytotoxic copper ferrite; zinc ferrite; nanoparticles; cytotoxic

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kanagesan, S.; Hashim, M.; AB Aziz, S.; Ismail, I.; Tamilselvan, S.; Alitheen, N.B.; Swamy, M.K.; Purna Chandra Rao, B. Evaluation of Antioxidant and Cytotoxicity Activities of Copper Ferrite (CuFe2O4) and Zinc Ferrite (ZnFe2O4) Nanoparticles Synthesized by Sol-Gel Self-Combustion Method. Appl. Sci. 2016, 6, 184.

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