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Appl. Sci. 2016, 6(8), 222; doi:10.3390/app6080222

Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract

Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 143 701, South Korea
Department of Chemistry, D.K.M. College for Women, Vellore, Tamil Nadu 632001, India
Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam-632 509, Vellore District, Tamil Nadu, India
Department of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, India
Authors to whom correspondence should be addressed.
Academic Editor: Raed Abu-Reziq
Received: 17 June 2016 / Revised: 28 July 2016 / Accepted: 29 July 2016 / Published: 9 August 2016
View Full-Text   |   Download PDF [4177 KB, uploaded 9 August 2016]   |  


This study reports the biological synthesis of gold nanoparticles (AuNPs) by the reduction of HAuCl4 by using of Eclipta prostrata leaf extract as the reducing and stabilizing agent. AuNPs were characterized using Ultraviolet–visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier Transform-Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), High Resolution-Transmission Electron Microscopy (HRTEM), and Energy Dispersive X-ray analysis (EDAX). The UV-visible spectrum of the synthesized AuNPs showed surface plasmon resonance (SPR) around 534 nm. The face-centered cubic (FCC) structure of the AuNPs was confirmed by XRD peaks at 38.10°, 44.13°, 64.43°, and 77.32°, which correspond to (111), (200), (220), and (311) miller indices, respectively, with clear circular spots in the selected area electron diffraction (SAED). FTIR measurements showed the AuNPs having a coating of phenolic compounds, indicating a possible role of biomolecules responsible for capping and efficient stabilization of the AuNPs. The HRTEM images determined the particles are spherical, hexagonal, and triangular in shape, with an average size of 31 ± 1.6 nm. The synthesized AuNPs show good antibacterial, antioxidant, and cytotoxic activity. The outcomes of this study indicate that these nanoparticles could be effectively utilized in pharmaceutical, biotechnological, and biomedical applications. View Full-Text
Keywords: gold nanoparticles; Eclipta prostrata; characterization; antibacterial activity; cytotoxic activity gold nanoparticles; Eclipta prostrata; characterization; antibacterial activity; cytotoxic activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rajakumar, G.; Gomathi, T.; Abdul Rahuman, A.; Thiruvengadam, M.; Mydhili, G.; Kim, S.-H.; Lee, T.-J.; Chung, I.-M. Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract. Appl. Sci. 2016, 6, 222.

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