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Appl. Sci. 2016, 6(3), 72; doi:10.3390/app6030072

Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy

1
Department of Electrical and Electronic Engineering Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan
2
Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Peter Hauri
Received: 21 November 2015 / Revised: 3 February 2016 / Accepted: 24 February 2016 / Published: 3 March 2016
(This article belongs to the Special Issue Frontiers in Terahertz Science and Technology)
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Abstract

To assess the possibility of terahertz technology for the determination of drug concentration in blood, we endeavored to apply a terahertz (THz) attenuated total reflection (ATR) method to measure the levels of theophylline in saline. A change in reflected THz wave amplitude was observed in a theophylline concentration-dependent manner. This result was obtained with simple measurements of comparisons of the amplitude of the reflected wave, and suggests that it is possible to monitor concentration changes of drugs in liquid material using THz ATR measurements. View Full-Text
Keywords: terahertz; attenuated total reflection; therapeutic drug monitoring terahertz; attenuated total reflection; therapeutic drug monitoring
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takeya, K.; Muto, K.; Ishihara, Y.; Kawase, K. Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy. Appl. Sci. 2016, 6, 72.

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