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Appl. Sci. 2016, 6(12), 444; doi:10.3390/app6120444

Biodegradable Nanoparticles Made of Amino-Acid-Based Ester Polymers: Preparation, Characterization, and In Vitro Biocompatibility Study

1
Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Tbilisi 0159, Georgia
2
Cellular Immunology Laboratory, Agricultural University of Georgia, Tbilisi 0159, Georgia
*
Author to whom correspondence should be addressed.
Academic Editor: Jordi Puiggalí
Received: 20 November 2016 / Revised: 5 December 2016 / Accepted: 8 December 2016 / Published: 17 December 2016
(This article belongs to the Special Issue Biodegradable and Biocompatible Nanoparticles)
View Full-Text   |   Download PDF [2630 KB, uploaded 17 December 2016]   |  

Abstract

A systematic study of fabricating nanoparticles (NPs) by cost-effective polymer deposition/solvent displacement (nanoprecipitation) method has been carried out. Five amino acid based biodegradable (AABB) ester polymers (four neutral and one cationic), four organic solvents miscible with water, and eight surfactants were tested for the fabrication of the goal NPs. Depending on the nature of the AABB polymers, organic solvents and surfactants, as well as on the fabrication conditions, the size (Mean Particle Diameter) of the NPs could be tuned within 42 ÷ 398 nm, the zeta-potential within 12.5 ÷ +28 mV. The stability (resuspendability) of the NPs upon storage (at room temperature and refrigerated) was tested as well. In Vitro biocompatibility study of the NPs was performed with four different stable cell lines: A549, HeLa (human); RAW264.7, Hepa 1-6 (murine). Comparing the NPs parameters, their stability upon storage, and the data of biological examinations the best were found: As the AABB polymer, a poly(ester amide) composed of l-leucine, 1,6-hexanediol and sebacic acid–8L6, as a solvent (organic phase—DMSO), and as a surfactant, Tween 20. View Full-Text
Keywords: amino acids; biodegradable polymers; nanoprecipitation; nanoparticles; systematic study; nanoparticles stability; in vitro cell compatibility amino acids; biodegradable polymers; nanoprecipitation; nanoparticles; systematic study; nanoparticles stability; in vitro cell compatibility
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MDPI and ACS Style

Kantaria, T.; Kantaria, T.; Kobauri, S.; Ksovreli, M.; Kachlishvili, T.; Kulikova, N.; Tugushi, D.; Katsarava, R. Biodegradable Nanoparticles Made of Amino-Acid-Based Ester Polymers: Preparation, Characterization, and In Vitro Biocompatibility Study. Appl. Sci. 2016, 6, 444.

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