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Appl. Sci. 2016, 6(12), 436; doi:10.3390/app6120436

Poly(α-hydroxy Acids)-Based Cell Microcarriers

Department of Mining-Metallurgy Engineering and Materials Science & POLYMAT, Faculty of Engineering, University of the Basque Country (UPV/EHU), Bilbao 480130, Spain
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Academic Editor: Jordi Puiggalí
Received: 27 October 2016 / Revised: 10 December 2016 / Accepted: 12 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Biodegradable and Biocompatible Nanoparticles)
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Abstract

Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On the other hand, by simple emulsion-solvent evaporation techniques, microspheres of controlled size and size distribution can be fabricated. The resulting microspheres can be further surface-modified to enhance cell adhesion and proliferation. As a result of this process, biodegradable microcarriers with advanced functionalities and surface properties that can be directly employed as injectable cell microcarriers are obtained. View Full-Text
Keywords: polylactide; poly(α-hydroxyacids); cell microcarriers; microparticles; tissue engineering polylactide; poly(α-hydroxyacids); cell microcarriers; microparticles; tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Larrañaga, A.; Sarasua, J.-R. Poly(α-hydroxy Acids)-Based Cell Microcarriers. Appl. Sci. 2016, 6, 436.

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