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Appl. Sci. 2016, 6(1), 27; doi:10.3390/app6010027

Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran
Medical Biotechnology Research Center, Guilan University of Medical Sciences, Rasht 4477166595, Iran
Author to whom correspondence should be addressed.
Academic Editor: Rajender S. Varma
Received: 13 November 2015 / Revised: 18 December 2015 / Accepted: 29 December 2015 / Published: 19 January 2016
View Full-Text   |   Download PDF [1467 KB, uploaded 19 January 2016]   |  


Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry. View Full-Text
Keywords: Alum; bispyrazole derivatives; 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one; Carbonyl compound; Solvent-free conditions Alum; bispyrazole derivatives; 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one; Carbonyl compound; Solvent-free conditions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zolfigol, M.A.; Khazaei, A.; Karimitabar, F.; Hamidi, M. Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives. Appl. Sci. 2016, 6, 27.

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