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Open AccessCommunication
Appl. Sci. 2015, 5(4), 1076-1085; doi:10.3390/app5041076

The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging

1
Department of Neurology, Pudong People’s Hospital, Shanghai 201299, China
2
Department of Radiology, Pudong People’s Hospital, Shanghai 201299, China
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe Lambin
Received: 26 August 2015 / Revised: 25 October 2015 / Accepted: 27 October 2015 / Published: 10 November 2015
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
View Full-Text   |   Download PDF [3218 KB, uploaded 10 November 2015]   |  

Abstract

The most notable obstacle of brain cancer diagnosis is the inability of delivering imaging agents across the blood-brain barrier (BBB). Recently, quantum dots (QDs) has been demonstrated as an ideal image agent for brain imaging due to their ultra-small size for crossing BBB. The plolyamidoamine dendrimers modified CdTe/CdS core/shell near-infrared (NIR) region QDs was successfully synthesized in aqueous solution, and then was characterized by UV-vis absorption, photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), etc. Our results reveal that the dendrimers modified CdTe/CdS QDs exhibits good water-dispersity and stable NIR fluorescence in various biological environments. In addition, this NIR QDs demonstrates a good biocompatibility and sensitive photoluminescence responses in brain tumor cell imaging. In a word, this type of dendrimers modified NIR CdTe/CdS QDs has huge potential applications in brain imaging. View Full-Text
Keywords: noninvasive cancer diagnosis; brain imaging; nanotechnology; near infrared; quantum dots noninvasive cancer diagnosis; brain imaging; nanotechnology; near infrared; quantum dots
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bai, Q.; Zhao, Z.; Sui, H.; Chen, J.; Xie, X.; Wen, F. The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging. Appl. Sci. 2015, 5, 1076-1085.

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