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Appl. Sci. 2014, 4(2), 171-179; doi:10.3390/app4020171
Article

A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

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Received: 16 November 2013 / Revised: 25 February 2014 / Accepted: 18 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
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Abstract

Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction.
Keywords: Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shearouse, W.C.; Shumba, M.Z.; Mack, J. A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry. Appl. Sci. 2014, 4, 171-179.

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