Dry Distillation of Radioiodine from TeO2 Targets
Received: 26 July 2013 / Revised: 8 October 2013 / Accepted: 21 October 2013 / Published: 28 October 2013
Cited by 1 | PDF Full-text (1145 KB) | HTML Full-text | XML Full-text
As medical cyclotrons are becoming more abundant, 123I and 124I are getting more attention as alternatives to 131I for diagnostics of thyroid disease. Both 123I and 124I provide better diagnostics, deliver less dose to patients and both reduce
[...] Read more.
As medical cyclotrons are becoming more abundant, 123
I and 124
I are getting more attention as alternatives to 131
I for diagnostics of thyroid disease. Both 123
I and 124
I provide better diagnostics, deliver less dose to patients and both reduce the risk of thyroid stunning, facilitating subsequent therapy. Dry distillation of radioiodine from tellurium dioxide targets has become the standard approach to producing these radioiodines. Setting up such a production of radioiodine is associated with a lengthy optimization of the process and for this purpose natural tellurium is often used for economical reasons. In this paper, the distillation parameters are scrutinized to ensure optimal distillation temperature, in order to minimize time spent and prevent loss of expensive target material. It is further demonstrated how the individual iodine isotopes, produced from proton bombardment of nat
Te, will diffuse out of the target in a time dependent ratio. We believe the effect is due to the isotopes having their maximum cross section at different energies. The individual isotopes produced will thus have their highest concentration at different depths in the target. This results in individual mean diffusion lengths and diffusion times for the different isotopes.