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Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis
Abdominal Imaging & Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, USA
* Author to whom correspondence should be addressed.
Received: 12 April 2012; in revised form: 11 May 2012 / Accepted: 16 May 2012 / Published: 29 May 2012
Abstract: Angiogenesis, the growth of new capillary blood vessels, is central to the growth of tumors. Non-invasive imaging of tumor angiogenesis will allow for earlier detection of tumors and also the development of surrogate markers for assessing response to treatment. Steady state magnetic resonance imaging with magnetic nanoparticles is one method to assess angiogenesis. In this article we explain the theory behind steady state magnetic resonance imaging and review the available literature.
Keywords: angiogenesis; ultrasmall superparamagnetic iron oxide; magnetic resonance imaging
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McDermott, S.; Guimaraes, A.R. Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis. Appl. Sci. 2012, 2, 525-534.
McDermott S, Guimaraes AR. Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis. Applied Sciences. 2012; 2(2):525-534.
McDermott, Shaunagh; Guimaraes, Alexander R. 2012. "Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis." Appl. Sci. 2, no. 2: 525-534.