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Appl. Sci. 2012, 2(2), 525-534; doi:10.3390/app2020525

Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis

1,*  and 1,2
1 Abdominal Imaging & Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA 2 Athinoula A. Martinos Center for Biomedical Imaging, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, USA
* Author to whom correspondence should be addressed.
Received: 12 April 2012 / Revised: 11 May 2012 / Accepted: 16 May 2012 / Published: 29 May 2012
(This article belongs to the Special Issue Magnetic Nanoparticles: Synthesis, Properties and Applications)
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Angiogenesis, the growth of new capillary blood vessels, is central to the growth of tumors. Non-invasive imaging of tumor angiogenesis will allow for earlier detection of tumors and also the development of surrogate markers for assessing response to treatment. Steady state magnetic resonance imaging with magnetic nanoparticles is one method to assess angiogenesis. In this article we explain the theory behind steady state magnetic resonance imaging and review the available literature.
Keywords: angiogenesis; ultrasmall superparamagnetic iron oxide; magnetic resonance imaging angiogenesis; ultrasmall superparamagnetic iron oxide; magnetic resonance imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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McDermott, S.; Guimaraes, A.R. Magnetic Nanoparticles in the Imaging of Tumor Angiogenesis. Appl. Sci. 2012, 2, 525-534.

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