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Behav. Sci., Volume 1, Issue 1 (December 2011), Pages 1-30

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Editorial

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Open AccessEditorial Behavioral Sciences: An International, Open-Access, Peer Reviewed Journal
Behav. Sci. 2011, 1(1), 1-3; doi:10.3390/behavsci1010001
Received: 21 February 2011 / Accepted: 21 February 2011 / Published: 22 February 2011
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Abstract
On behalf of the Editorial Board and the editorial management staff of MDPI, it is my great pleasure to introduce this new journal Behavioral Sciences. Behavioral Sciences seeks to publish original research and scholarship contributing to our understanding of human behavior. The
[...] Read more.
On behalf of the Editorial Board and the editorial management staff of MDPI, it is my great pleasure to introduce this new journal Behavioral Sciences. Behavioral Sciences seeks to publish original research and scholarship contributing to our understanding of human behavior. The journal will provide a forum for work that furthers knowledge and stimulates research in the behavioral sciences. We are committed to building a diverse and methodologically rigorous literature of interest and benefit to behavioral and social scientists, as well as to clinical practitioners, educationalists, and the general public. [...] Full article

Research

Jump to: Editorial

Open AccessArticle Long-term Effects of Multiple Glucocorticoid Exposures in Neonatal Mice
Behav. Sci. 2011, 1(1), 4-30; doi:10.3390/behavsci1010004
Received: 10 December 2011 / Revised: 27 December 2011 / Accepted: 28 December 2011 / Published: 30 December 2011
Cited by 11 | PDF Full-text (5598 KB) | HTML Full-text | XML Full-text
Abstract
Glucocorticoids (GCs) such as dexamethasone (DEX) or betamethasone are repeatedly administered for up to a month to prematurely born infants as a treatment for chronic lung dysfunction. Results of clinical trials have shown that the use of GCs in these infants induces long-term
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Glucocorticoids (GCs) such as dexamethasone (DEX) or betamethasone are repeatedly administered for up to a month to prematurely born infants as a treatment for chronic lung dysfunction. Results of clinical trials have shown that the use of GCs in these infants induces long-term deficits in neuromotor function and cognition. We have previously shown that a single exposure to clinically relevant doses of DEX or other GCs in the mouse during a period corresponding to the human perinatal period produces a dramatic increase in apoptotic cell death of neural progenitor cells in the developing cerebellum. To provide a model approximating more chronic clinical dosing regimens, we evaluated possible behavioral effects resulting from repeated exposures to DEX and subsequent GC-induced neuronal loss where neonatal mouse pups were injected with 3.0 mg/kg DEX or saline on postnatal days 7, 9, and 11 (DEX3 treatment). Adult, DEX3-treated mice exhibited long-term, possibly permanent, neuromotor deficits on a complex activity wheel task, which requires higher-order motor co-ordination skills. DEX3 mice exhibited impaired performance on this task relative to saline controls in each of two independent studies involving separate cohorts of mice. Histopathology studies utilizing stereological neuronal counts conducted in behaviorally-tested mice showed that the DEX3 treatment resulted in a significant decrease in the number of neurons in the internal granule layer (IGL) of the cerebellum, although the number of neurons in the Purkinje cell layer were unchanged. The results suggest that multiple neonatal DEX exposures can produce chronic deficits in fine motor co-ordination that are associated with cerebellar IGL neuronal loss. Full article
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