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Med. Sci. 2018, 6(2), 50; https://doi.org/10.3390/medsci6020050

Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmonary Disease? What Do We Need to Add?

1
Hospital Universitario de Caracas, Facultad de Medicina, Los Chaguaramos, Universidad Central de Venezuela, 1053 Caracas, Venezuela
2
Servicio de Neumonología, Hospital Universitario de Caracas, Facultad de Medicina, Universidad Central de Venezuela, 1053 Caracas, Venezuela
*
Author to whom correspondence should be addressed.
Received: 7 April 2018 / Revised: 10 June 2018 / Accepted: 11 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue COPD Exacerbations)
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Abstract

Acute exacerbations in chronic obstructive pulmonary disease (AECOPD) are associated with increased mortality, rate of hospitalization, use of healthcare resources, and have a negative impact on disease progression, quality of life and lung function of patients with chronic obstructive pulmonary disease (COPD). There is an imperative need to homogenize the definition of AECOPD because the incidence of exacerbations has a significant influence or implication on treatment decision making, particularly in pharmacotherapy and could impact the outcome or change the statistical significance of a therapeutic intervention in clinical trials. In this review, using PubMed searches, we have analyzed the weaknesses and strengths of the different used AECOPD definitions (symptom-based, healthcare-based definition or the combinations of both), as well as the findings of the studies that have assessed the relationship of different biomarkers with the diagnosis, etiology and differential diagnosis of AECOPD and the progress towards the development of a more precise definition of COPD exacerbation. Finally, we have proposed a simple definition of AECOPD, which must be validated in future clinical trials to define its accuracy and usefulness in daily practice. View Full-Text
Keywords: Chronic obstructive pulmonary disease; acute exacerbation of chronic obstructive pulmonary disease; biomarkers; symptom-related definition; healthcare-based definition Chronic obstructive pulmonary disease; acute exacerbation of chronic obstructive pulmonary disease; biomarkers; symptom-related definition; healthcare-based definition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Montes de Oca, M.; Laucho-Contreras, M.E. Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmonary Disease? What Do We Need to Add? Med. Sci. 2018, 6, 50.

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