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Med. Sci. 2017, 5(4), 38; doi:10.3390/medsci5040038

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy

Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA
Author to whom correspondence should be addressed.
Received: 17 November 2017 / Revised: 12 December 2017 / Accepted: 14 December 2017 / Published: 18 December 2017
(This article belongs to the Special Issue Polyamine Metabolism in Disease and Polyamine-Targeted Therapies)
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Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (Curcuma longa), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues. Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs. This review summarizes the results of curcumin exposure with regard to the modulation of polyamine metabolism and discusses the potential utility of this natural compound in conjunction with the exploitation of dysregulated polyamine metabolism in chemopreventive and chemotherapeutic settings. View Full-Text
Keywords: curcumin; diferuloylmethane; ornithine decarboxylase; polyamine; NF-κB; chemoprevention; carcinogenesis; polyphenol curcumin; diferuloylmethane; ornithine decarboxylase; polyamine; NF-κB; chemoprevention; carcinogenesis; polyphenol

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Murray-Stewart, T.; Casero, R.A. Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy. Med. Sci. 2017, 5, 38.

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