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Med. Sci. 2017, 5(4), 24; doi:10.3390/medsci5040024

Assessment of Hepatitis B Viral Infection as a Predictor of Hepatic Enzymes and Compounds Alteration among Antenatal Patients

1
Department of Biological Sciences, Faculty of Science, Nigeria Police Academy, Wudil, P.M.B. Kano 3474, Kano State, Nigeria
2
Department of Microbiology, Kano University of Science and Technology, Wudil, P.M.B. Kano 3244, Kano State, Nigeria
*
Author to whom correspondence should be addressed.
Received: 28 August 2017 / Revised: 2 October 2017 / Accepted: 16 October 2017 / Published: 18 October 2017
(This article belongs to the Section Hepatic and Gastroenterology Diseases)
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Abstract

Worldwide, hepatitis B viral (HBV) infection continues to be a major public health issue. The study was aimed at assessing HBV infection as a predictor of hepatic enzymes and compounds alteration among antenatal patients in Kano State, Nigeria. Sera were screened for HBV markers using immunochromatograhy and ELISA. Serum levels of alkaline phosphatase (ALP), asphatate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin were also determined. Out of the 160 patients, 6.9% and 31.3% tested positive for HBsAg and HBcAb, respectively. None tested positive for HBeAg. These markers also appeared in other combinations. Of the HBsAg seropositives, 72.7% showed abnormal levels of both AST and ALP, 36.7% showed abnormal levels of both total and direct bilirubin, 9.1% showed abnormal levels of albumin, and none showed abnormal levels of ALT. HBsAg seropositivity shows significant association with ALP elevation (p = 0.02).The study revealed that few subjects (1.3%) that tested positive for HBsAg and HBeAb with normal ALT were in the inactive carrier phase of chronic hepatitisand6.9% that were seronegatives for all HBV markers equally had altered hepatic enzymes. The presence of HBeAg in the serum during HBV infection seems to cause a marked elevation of ALT level, while the reverse happens if HBeAg is absent. HBV infection can alter levels of hepatic enzymes and compounds and thus serve as one of its predictors, however; pregnancy can also lead to some of these alterations, which makes it difficult to establish the origin of these alterations among antenatal patients. View Full-Text
Keywords: hepatitis B virus; prevalence; hepatic enzymes; liver function tests; predictor; antenatal patients hepatitis B virus; prevalence; hepatic enzymes; liver function tests; predictor; antenatal patients
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MDPI and ACS Style

Abulude, O.A.; Ahmed, I.; Sadisu, F.U. Assessment of Hepatitis B Viral Infection as a Predictor of Hepatic Enzymes and Compounds Alteration among Antenatal Patients. Med. Sci. 2017, 5, 24.

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