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Med. Sci. 2017, 5(2), 8; doi:10.3390/medsci5020008

Serum Creatine Kinase-MB Isoenzyme Activity among Subjects with Uncomplicated Essential Hypertension: Any Sex Differences

1
Department of Medical Laboratory Science, University of Benin, Benin City 300283, Nigeria
2
Defence Reference Laboratory, Health institution, Abuja-Nigeria, FCT-Abuja 900211, Nigeria
*
Author to whom correspondence should be addressed.
Academic Editor: Rainer Schulz
Received: 3 March 2017 / Revised: 5 April 2017 / Accepted: 21 April 2017 / Published: 27 April 2017
(This article belongs to the Section Cardiovascular Disease)
View Full-Text   |   Download PDF [226 KB, uploaded 27 April 2017]

Abstract

Hypertension (high blood pressure) is a major health challenge and more women than men are affected by the condition. Complications as a result of this condition often lead to disabilities and premature death. The objective of this study was to evaluate creatine kinase-MB (CK-MB) activity in uncomplicated hypertension and to know whether sex differences exist in the activity of the enzyme. Serum creatine kinase-MB isoenzyme activity, troponin I, and lipid profile were evaluated in 140 male and 100 female Nigerians with hypertension. The control group was comprised of 100 (50 males and 50 females) normotensive subjects. Measured parameters were assayed using Selectra Pros chemistry analyzer. The means were compared between males and females using Students’t-test. The mean CK-MB activity of the female hypertensive subjects was significantly higher (p < 0.001) than the males. Similarly, the mean cardiac troponin I (cTnI) of the female hypertensive subjects was significantly higher (p < 0.001) than the males. Conversely, the mean CK-MB activity of the female normotensive subjects was significantly lower (p < 0.001) than the male counterparts. There was no difference in the levels of cTnI between male and female normotensive subjects. Serum CK-MB activity was higher in female than male hypertensive subjects. In the light of these results, cardiac markers should be routinely done in the evaluation of hypertensive subjects and sex-specific consideration may be recognized in the management of these patients. View Full-Text
Keywords: cardiovascular events; creatine kinase-MB isoenzyme; hypertension; troponin I cardiovascular events; creatine kinase-MB isoenzyme; hypertension; troponin I
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Emokpae, M.A.; Nwagbara, G.O.N.A. Serum Creatine Kinase-MB Isoenzyme Activity among Subjects with Uncomplicated Essential Hypertension: Any Sex Differences. Med. Sci. 2017, 5, 8.

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