Next Article in Journal
Acknowledgement to Reviewers of Medical Sciences in 2016
Previous Article in Journal
A Comparative Evaluation of Gait between Children with Autism and Typically Developing Matched Controls
Previous Article in Special Issue
Why Oats Are Safe and Healthy for Celiac Disease Patients
Article Menu

Export Article

Open AccessArticle
Med. Sci. 2017, 5(1), 2; doi:10.3390/medsci5010002

HLA Typing and Celiac Disease in Moroccans

1
National Research Council (CNR)-Institute of Translational Pharmacology, U.O.S. L’Aquila, Via Carducci 32, 67100 L’Aquila, Italy
2
Mohammed V-Souissi University, 10000 Rabat, Morocco
3
Medicine C, Department of Gastroenterology, Ibn Sina Hospital, 10000 Rabat, Morocco
4
Institute National d’Hygiene, 10000 Rabat, Morocco
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Megiorni
Received: 30 September 2016 / Revised: 7 December 2016 / Accepted: 22 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Genetics of Celiac Disease)
View Full-Text   |   Download PDF [1440 KB, uploaded 6 January 2017]   |  

Abstract

Genetic and environmental factors are responsible for differences in the prevalence of some diseases across countries. Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) has been fast increasing in prevalence in North Africa; but few immunogenetic data are available for this area, in which a high prevalence of the disease has been described. In this report, we assess and discuss results of HLA class II (HLA-DQA1/DQB1/DRB1) typing in Moroccan patients with CD and compare them with a control population from Morocco—genetically well characterized—and with other North African, Mediterranean, and European populations. The classical HLA-DQ associations were confirmed in Moroccans with CD. The high frequency of DQ2.5 homozygosity (45.2%) found in Moroccans with CD was noteworthy as compared with other populations (23%–32%). The genetic risk gradient for CD, identified by previous studies, has been confirmed in Moroccans with some differences, mainly concerning DQ8 genotypes. This study provides the immunogenetic framework of CD in Moroccans and confirms the need to learn more about associations with additional HLA and non-HLA genetic factors. View Full-Text
Keywords: celiac disease; HLA; Morocco; population; North Africa celiac disease; HLA; Morocco; population; North Africa
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Piancatelli, D.; Ben El Barhdadi, I.; Oumhani, K.; Sebastiani, P.; Colanardi, A.; Essaid, A. HLA Typing and Celiac Disease in Moroccans. Med. Sci. 2017, 5, 2.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Med. Sci. EISSN 2076-3271 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top