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Med. Sci. 2016, 4(4), 22; doi:10.3390/medsci4040022

Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus

1
Rheumatology Laboratory, Department of Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur 208024, India
2
Department of Biotechnology, Baba Saheb Bhimrao Ambedkar University, Lucknow 226025, India
3
Internal Medicine Department, Regency Hospital, Sarvoday Nagar, Kanpur 208005, India
4
Department of Biochemistry, Integral University, Lucknow 226026, India
*
Author to whom correspondence should be addressed.
Academic Editor: Gaetano Santulli
Received: 19 October 2016 / Revised: 1 December 2016 / Accepted: 5 December 2016 / Published: 9 December 2016
View Full-Text   |   Download PDF [205 KB, uploaded 9 December 2016]

Abstract

Iron overload is increasingly being connected to insulin resistance in Type 2 Diabetes Mellitus (T2DM) patients. Free iron causes the assembly of reactive oxygen species that invariably steer the body’s homeostasis towards oxidative stress-mediated diabetic complications. This study aims to assess the serum iron, total iron binding capacity (TIBC), and percentage transferrin saturation (Tsat) of 150 subjects divided into three groups (I,II,III) of 50. Healthy individuals (controls) constituted Group I. Group II consisted of T2DM patients with optimal glycaemic control. T2DM patients with suboptimal glycaemic control formed group III. Mean serum free iron concentration was 105.34 ± 3.5, 107.33 ± 3.45, and 125.58 ± 3.45 μg/dL in Group I, Group II, and Group III, respectively. Mean serum TIBC concentration in Group I, Group II, and Group III was 311.39 ± 5.47, 309.63 ± 6.1, and 284.2 ± 3.18 μg/dL, respectively. Mean serum transferrin saturation (%) in Group I, Group II, and Group III was 34.17 ± 1.21, 35.02 ± 1.2, and 44.39 ± 1.07, respectively. The difference between TIBC, mean serum free iron concentration, and transferrin saturation between Group I and Group III (for all, p values <0.001), as well as between Group II and Group III (p values 0.0012, 0.0015, and <0.0001, respectively) was statistically significant. The fasting plasma glucose values of Groups II and III were significantly higher than those of Group I, (p < 0.0001). Glycated haemoglobin (HbA1c) values were also shown to increase from Group I to II and then III, and the increase was highly significant (all p values <0.0001). Thus, decreased glycaemic control and an increase in the glycation of haemoglobin was the key to elevation in serum iron values and alterations in other parameters. However, a significant correlation was absent between serum iron and HbA1c (r = 0.05) and transferrin saturation (r = 0.0496) in Group III. View Full-Text
Keywords: T2DM; glycaemic control; serum Iron; Transferrin saturation; Kanpur; North India T2DM; glycaemic control; serum Iron; Transferrin saturation; Kanpur; North India
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Misra, G.; Bhatter, S.K.; Kumar, A.; Gupta, V.; Khan, M.Y. Iron Profile and Glycaemic Control in Patients with Type 2 Diabetes Mellitus. Med. Sci. 2016, 4, 22.

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