Next Article in Journal
Development of a Safety Management Web Tool for Horse Stables
Previous Article in Journal
Wildlife in U.S. Cities: Managing Unwanted Animals
Previous Article in Special Issue
Lameness Detection in Dairy Cows: Part 2. Use of Sensors to Automatically Register Changes in Locomotion or Behavior
Article Menu

Export Article

Open AccessReview
Animals 2015, 5(4), 1114-1135; doi:10.3390/ani5040400

Digital Dermatitis in Cattle: Current Bacterial and Immunological Findings

Infectious Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jonathan Huxley and Clive J. Phillips
Received: 30 May 2015 / Revised: 16 October 2015 / Accepted: 23 October 2015 / Published: 11 November 2015
(This article belongs to the Special Issue Dairy Cow Mobility and Lameness)
View Full-Text   |   Download PDF [1274 KB, uploaded 11 November 2015]   |  

Simple Summary

Digital dermatitis causes lameness in cattle. Numerous studies have identified multiple bacteria associated with these painful lesions. Several types of a spiral shaped bacteria, Treponema species, are thought to play a role in disease development. Little is known about the immune response to bacteria involved in digital dermatitis. Local inflammatory cells can contribute to the non-healing nature of the disease. Animal models of infection are required to develop effective vaccines and treatments.

Abstract

Globally; digital dermatitis is a leading form of lameness observed in production dairy cattle. While the precise etiology remains to be determined; the disease is clearly associated with infection by numerous species of treponemes; in addition to other anaerobic bacteria. The goal of this review article is to provide an overview of the current literature; focusing on discussion of the polybacterial nature of the digital dermatitis disease complex and host immune response. Several phylotypes of treponemes have been identified; some of which correlate with location in the lesion and some with stages of lesion development. Local innate immune responses may contribute to the proliferative, inflammatory conditions that perpetuate digital dermatitis lesions. While serum antibody is produced to bacterial antigens in the lesions, little is known about cellular-based immunity. Studies are still required to delineate the pathogenic traits of treponemes associated with digital dermatitis; and other host factors that mediate pathology and protection of digital dermatitis lesions. View Full-Text
Keywords: digital dermatitis; treponemes; anaerobes; immune response; dairy cattle digital dermatitis; treponemes; anaerobes; immune response; dairy cattle
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wilson-Welder, J.H.; Alt, D.P.; Nally, J.E. Digital Dermatitis in Cattle: Current Bacterial and Immunological Findings. Animals 2015, 5, 1114-1135.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Animals EISSN 2076-2615 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top