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Animals 2015, 5(4), 1021-1033; doi:10.3390/ani5040396

Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions

1
Department of Farm Animals and Veterinary Public Health, Institute of Animal Nutrition and Functional Plant Compounds, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria
2
Department of Farm Animals and Veterinary Public Health, University Clinic for Swine, Vetmeduni Vienna, Veterinaerplatz 1, Vienna 1210, Austria
3
Veterinary Clinic Dr. Leopold Podstatzky-Lichtenstein, Wels 4600, Austria
4
Department of Farm Animals and Veterinary Public Health, University Clinic for Ruminants, Vetmeduni Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Clive J. C. Phillips
Received: 31 August 2015 / Revised: 17 September 2015 / Accepted: 8 October 2015 / Published: 13 October 2015
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Simple Summary

This research established an association between lactation number and milk production and metabolic and inflammatory responses in high-producing dairy cows affected by left abomasal displacement in small-scaled dairy farms. The study showed metabolic alterations, liver damage, and inflammation in the sick cows, which were further exacerbated with increasing lactation number and milk yield of the cows.

Abstract

Left displaced abomasum (LDA) is a severe metabolic disease of cattle with a strong negative impact on production efficiency of dairy farms. Metabolic and inflammatory alterations associated with this disease have been reported in earlier studies, conducted mostly in large dairy farms. This research aimed to: (1) evaluate metabolic and inflammatory responses in dairy cows affected by LDA in small-scaled dairy farms; and (2) establish an Animals 2015, 5 1022 association between lactation number and milk production with the outcome of metabolic variables. The cows with LDA had lower serum calcium (Ca), but greater concentrations of non-esterified fatty acids (NEFA) and beta-hydroxy-butyrate (BHBA), in particular when lactation number was >2. Cows with LDA showed elevated levels of aspartate aminotransferase, glutamate dehydrogenase, and serum amyloid A (SAA), regardless of lactation number. In addition, this study revealed strong associations between milk yield and the alteration of metabolic profile but not with inflammation in the sick cows. Results indicate metabolic alterations, liver damage, and inflammation in LDA cows kept under small-scale farm conditions. Furthermore, the data suggest exacerbation of metabolic profile and Ca metabolism but not of inflammation and liver health with increasing lactation number and milk yield in cows affected by LDA. View Full-Text
Keywords: metabolic disease; acute phase response; periparturient dairy cow; milk yield; cow welfare metabolic disease; acute phase response; periparturient dairy cow; milk yield; cow welfare
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Klevenhusen, F.; Humer, E.; Metzler-Zebeli, B.; Podstatzky-Lichtenstein, L.; Wittek, T.; Zebeli, Q. Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions. Animals 2015, 5, 1021-1033.

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